Hum. Thinking through this myself... And making some heroic assumptions.
1) The body isn't saturated at 6m - certainly the slow tissues aren't. However I'm going to make a simplifying assumption that the body is mainly fast tissues that are saturated. I know this is wrong!
2) The safe degree of over-saturation at the surface is 1.6atm (Bulhmann's M0 value)
3) The safe degree of oversaturation at 6m is roughly 1.6 x ambient, = 2.56 bar, call it 2.6 bar between friends.
4) Hence difference in tissue saturation between arriving at 6m stop, and being ok to surface (ie leaving 6m stop) is 1.0 bar.
5) Solubility of Helium in blood is: 0.008 ml / ml-atm [1] or 8ml per litre of blood in sheep.
6) If a 100kg person is 50% blood and other fast tissues (brain etc) then that would be 0.4 litres of He off-gassed if breathing pure He.
7) Hence 0.2 litres off-gassed if breathing 50% He before reaching 6m.
8) Given a tidal volume of 2 litres, that's about 10% so you'd expect to see the ppO2 drop from 1.6 to 1.44 over the course of deco.
Janos
[1] - Source: snip
Was thinking about this also today.
Assuming total saturation and a 1.6 M value that means the worse the body can arriving at 6m would be 1.6 x 1.6 = 2.6 (between friends LOL)
The figure from my earlier post of 1.5mg per L per atm
Then take your 100kg diver - assuming we are mostly water (I think its about 60%) we get 100L
So worse case total breathing pure Helium would be 2.6 *1.5*100 = 390mg gas or .39g
Assuming that we could surface at when tissues reach 1.6 that means we'd leave 6m after we'd off gassed (1.6/2.56*0.39) 0.24g of Helium.
.24g of Helium has a volume of (.24/4*22.4) = 1.34L at surface and at 6m 0.84L (which interestingly is the same figure as your example since you say 50% heliium and 50% body composition water and fast tissues giving .21L)
Since worse worse case you have 0.2 (Janos) - 0.8 (me) L offgassing into a lung and loop total volume of something like 10L (much more than your tidal volume example) giving us 2-8%. So PO2 drop of .12 over entire deco.
I would say we are probably more conservative by between 2 and 10x so likely off gassed Helium is much less important than water vapour and any other factor affecting readout of PO2.